abstract：:Angiotensin II (Ang II) as an important pathogenic factor, has been implicated in the pathogenesis of hypertension and associated renal injury, and inhibition of Ang II can reduce renal inflammation and exert renal protective effects. In the present study, we determine the infiltration of Th22 cells in kidney and seru...

journal_title：International immunopharmacology

authors： Zhong Y,Tang R,Lu Y,Wang W,Xiao C,Meng T,Ao X,Li X,Peng L,Kwadwo Nuro-Gyina P,Zhou Q

更新日期：2020-10-01 00:00:00

abstract：:Epilepsy is one of the most common neurological diseases. It adversely affects cognitive function. Neuroinflammation has been widely recognized as an important factor involved in the pathophysiology of epilepsy. Cyclooxygenase (COX) is a type of oxidoreductase enzyme that acts in the metabolic pathway converting arach...

journal_title：International immunopharmacology

authors： Zhu X,Yao Y,Yang J,Zhengxie J,Li X,Hu S,Zhang A,Dong J,Zhang C,Gan G

更新日期：2020-10-01 00:00:00

abstract：:Psoriasis is a chronic inflammatory skin disease featured by excessive proliferation of keratinocytes, clearly defined round erythema and dry, scaly plaques, long-term inflammatory cells infiltration in skin lesions. However, the physiopathological mechanism of psoriasis is still not clearly understood. Neuropeptides,...

journal_title：International immunopharmacology

authors： Zhang Y,Zhang H,Jiang B,Yan S,Lu J

更新日期：2020-10-01 00:00:00

abstract：:Anemoside B4 (B4) is a compound extracted from Pulsatilla chinensis(P. chinensis). Pharmacological studies have proved that it has certain anti-inflammatory activity. Acute ulcerative colitis (ulcerative colitis) is a non-specific inflammatory disease whose pathogenesis is not completely known, and there is no effecti...

journal_title：International immunopharmacology

authors： Ma H,Zhou M,Duan W,Chen L,Wang L,Liu P

更新日期：2020-10-01 00:00:00

abstract：:Asthma is an inflammatory disorder of the airways dominated by a Th2-type pattern. Recently, an emerging interest arises whether transient receptor potential ankyrin 1 (TRPA1) plays a potential role in the adaptive immune response. In this study, the role of TRPA1 in the development and exacerbation of asthma was expl...

journal_title：International immunopharmacology

authors： Li M,Fan X,Yue Q,Hu F,Zhang Y,Zhu C

更新日期：2020-09-01 00:00:00

abstract：:Depression has been commonly associated with type 1 diabetes (T1D) and insulin covalently modified with catecholestrogens (CEs) was found in serum of these T1D patients. This study aimed to know whether depression link to higher antibodies against estrogenized insulin in T1D. ELISA (direct binding and competition) and...

journal_title：International immunopharmacology

authors： Khan WA,Malik A,Khan MWA

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:The activities of tumor-infiltrating immune cells (TIICs) play an important role in the outcomes of many types of cancers. Here, we sought to describe the landscape of TIICs in testicular germ cell tumors (TGCT) and to develop a prognostic model based on this information. METHODS:The Cell-type Identification...

journal_title：International immunopharmacology

authors： Wang Y,Ji C,Liu J,Wang Y,Song N,Cao P

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is attracting considerable attention due to disease acceleration and substantial mortality. Macrophages are known to regulate the fibrotic process in idiopathic pulmonary fibrosis. OBJECTIVE:We investigated if two new macrophage-specific serum bio...

journal_title：International immunopharmacology

authors： Zou R,Gui X,Zhang J,Tian Y,Liu X,Tian M,Chen T,Wu H,Chen J,Dai J,Cai H

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Interleukin 7 receptor (IL-7R) is a member of the type I cytokine receptor family, which affects the occurrence of various tumors by forming a signaling complex with its ligand Interleukin 7 (IL-7). This study aimed to explore the potential relationships of IL-7R polymorphisms with breast cancer susceptibili...

journal_title：International immunopharmacology

authors： Wang Z,Wang X,Gao Y,Wang Y,Xu M,Han Q,Zhao X

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:There is no vaccine or specific antiviral treatment for HCoVs infection. The use of type I interferons for coronavirus is still under great debate in clinical practice. MATERIALS AND METHODS:A literature search of all relevant studies published on PubMed, Cochrane library, Web of Science database, Science D...

journal_title：International immunopharmacology

authors： Yu C,Kang L,Chen J,Zang N

更新日期：2020-09-01 00:00:00

abstract：:There is increasing appreciation of the critical pathogenic role of IL-17 in inflammation and autoimmune diseases, which could be produced from both adaptive Th17 cells and innate γδ T cells. Existing evidences suggest that IL-2 is important for in vivo accumulation of IL-17+ γδ T cells, leaving the mechanisms still e...

journal_title：International immunopharmacology

authors： Li T,Zhou Y,Sun X,Bian Y,Wang K,Guo Q,Wang Q,Qiu F

更新日期：2020-09-01 00:00:00

abstract：:Isolating and purifying liver immune cells are crucial for observing the changes in intrahepatic immune responses during the development of liver diseases and exploring the potential immunological mechanisms. Therefore, the aim of this study was to provide an optimal protocol for isolating immune cells with a high yie...

journal_title：International immunopharmacology

authors： Shi W,Wang Y,Zhang C,Jin H,Zeng Z,Wei L,Tian Y,Zhang D,Sun G

更新日期：2020-08-01 00:00:00

abstract：:Bacillus anthracis is a lethal agent of anthrax disease and the toxins are required in anthrax pathogenesis. The anthrax lethal toxin can trigger NLRP1b inflammasome activation and pyroptosis. Although the underlying mechanism is well understood, the medications targeting the NLRP1b inflammasome are not available in t...

journal_title：International immunopharmacology

authors： Wang J,Yang D,Shen X,Wang J,Liu X,Lin J,Zhong J,Zhao Y,Qi Z

更新日期：2020-08-01 00:00:00

abstract：:Immunotherapy has recently become a powerful weapon against cancer. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) was the first immune checkpoint used for immunotherapy. However, CTLA-4-related mechanisms in various cancers have not been comprehensively investigated. This aim of this study was an in-depth inves...

journal_title：International immunopharmacology

authors： Zhang C,Chen J,Song Q,Sun X,Xue M,Yang Z,Shang J

更新日期：2020-08-01 00:00:00

abstract：:Urinary trypsin inhibitor (UTI), also known as ulinastatin, has been reported to protect multiple organs against inflammation- and/or injury-induced dysfunction. In the present study, we aimed to investigate the immunomodulation effects of a recombinant human ulinastatin (urinary trypsin inhibitor, UTI) (rhUTI) on spl...

journal_title：International immunopharmacology

authors： Qi AL,Wu Y,Dong N,Chai YF,Zhu XM,Yao YM

更新日期：2020-08-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic immuno-inflammatory disease of the central nervous system characterized by demyelination and axonal damage. Cognitive changes are common in individuals with MS since inflammatory molecules secreted by microglia interfere with the physiological mechanisms of synaptic plasticity. Acc...

journal_title：International immunopharmacology

authors： Araújo SMDR,Duarte-Silva E,Marinho CGS,Oliveira WH,França MER,Lós D,Peron G,Tomaz L,Bonfanti AP,Verinaud L,Peixoto CA

更新日期：2020-08-01 00:00:00

abstract：:Microglial inflammation induced by ischemic stroke aggravates brain damage. MicroRNAs (miRNAs) have emerged as pivotal regulators in ischemic stroke-induced inflammation in microglial cells. miR-665-3p has been reported as a critical inflammation-associated miRNA. However, whether miR-665-3p participates in regulating...

journal_title：International immunopharmacology

authors： Zhang X,Feng Y,Li J,Zheng L,Shao Y,Zhu F,Sun X

更新日期：2020-08-01 00:00:00

abstract：:Pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, has neuroprotective effects on permanent and transient cerebral ischemia in rats by alleviating autophagic/lysosomal defects and repressing calcium overload, respectively. Ischemic stroke triggers peripheral innate immune cells, mainly neutrophils and macrophage...

journal_title：International immunopharmacology

authors： Hou Y,Yang D,Zhang Q,Wang X,Yang J,Wu C

更新日期：2020-08-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) from blood vessel rupture results in parenchymal hematoma formation and neuroinflammation, ultimately leading to neurodegeneration. Several lines of evidence suggest that the severity of ICH-induced neural damage is exacerbated by infiltration of T-cells, monocytes, and especially neutro...

journal_title：International immunopharmacology

authors： Hijioka M,Futokoro R,Ohto-Nakanishi T,Nakanishi H,Katsuki H,Kitamura Y

更新日期：2020-08-01 00:00:00

abstract：:The objective was to evaluate the effects of antimicrobial peptide cathelicidin-BF (C-BF) treatment on diarrhea controlling, immune responses, intestinal inflammation, and intestinal barrier function in piglets with postweaning diarrhea. In this study, fifty-four weaned piglets with diarrhea were selected and treated ...

journal_title：International immunopharmacology

authors： Feng J,Wang L,Xie Y,Chen Y,Yi H,He D

更新日期：2020-08-01 00:00:00

abstract：:Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated the effects of Imperatorin on interleukin-1β (IL-1β) induced express...

journal_title：International immunopharmacology

authors： Ahmad N,Ansari MY,Bano S,Haqqi TM

更新日期：2020-08-01 00:00:00

abstract：:Brucellosis is the most common zoonotic disease worldwide and still there is no vaccine for human use. The commercial animal vaccines also have major problems that limit their use. Therefore, there is a need for an effective Brucella vaccine which is multivalent and produces a good protective immunity with minimal dis...

journal_title：International immunopharmacology

authors： Golshani M,Amani M,Amirzadeh F,Nazeri E,Davar Siadat S,Nejati-Moheimani M,Arsang A,Bouzari S

更新日期：2020-07-01 00:00:00

abstract：:There is increasing evidence that macrophages play an important role in the development and pathogenesis of diabetic nephropathy (DN) by secreting inflammatory cytokines. Exosomes are a family of extracellular vesicles that are secreted from almost all types of cells and associated with cell-to-cell communications. In...

journal_title：International immunopharmacology

authors： Zhu M,Sun X,Qi X,Xia L,Wu Y

更新日期：2020-07-01 00:00:00

abstract：:Neuroinflammation, characterized by the activation of microglia and astrocytes, is important in the pathogenesis of many neurological disorders, such as Alzheimer's disease. Nonsteroidal anti-inflammatory drugs (NSAIDs), a group of chemically heterogenous medications, are used widely in the treatment of inflammation. ...

journal_title：International immunopharmacology

authors： You M,Miao Z,Sienkiewicz O,Jiang X,Zhao X,Hu F

更新日期：2020-07-01 00:00:00

abstract：:The purpose of this study was the combination of curcumin and ovalbumin in free form or encapsulated into PLGA NPs (polylactic co-glycolic acid nanoparticles) to enhance their sublingual immunotherapy (SLIT) efficiency in mouse model of rhinitis allergic. PLGA NPs containing curcumin (CUR), ovalbumin (OVA) or both wer...

journal_title：International immunopharmacology

authors： Shahgordi S,Sankian M,Yazdani Y,Mashayekhi K,Hasan Ayati S,Sadeghi M,Saeidi M,Hashemi M

更新日期：2020-07-01 00:00:00

abstract：:Acute lung injury (ALI) is a severe disease characterized by several inflammatory responses in the lung with high mortality. We applied a mouse model of the pulmonary inflammation induced by the intratracheal instillation of bleomycin which is widely used to induce ALI and fibrosis in animal models. We hypothesized th...

journal_title：International immunopharmacology

authors： Lu CH,Chen CM,Ma J,Wu CJ,Chen LC,Kuo ML

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Ischaemic stroke is a lethal cerebrovascular disease that occurs worldwide. Astilbin is a natural flavonoid compound with various physiological activities. The purpose of this study was to investigate the neuroprotective effects of Astilbin after cerebral ischaemia reperfusion (I/R) injury. METHODS:The oxyg...

journal_title：International immunopharmacology

authors： Li Y,Wang R,Xue L,Yang Y,Zhi F

更新日期：2020-07-01 00:00:00

abstract：:Platelets have been proved to exacerbate influenza infection and its complications. Inhibition of platelet activation may be a feasible method for preventing severe infection and secondary acute lung injury (ALI). Isofraxidin (IFD) is a natural coumarin isolated from the plants Sarcandra glabra and Siberian ginseng, a...

journal_title：International immunopharmacology

authors： Jin L,Ying ZH,Yu CH,Zhang HH,Yu WY,Wu XN

更新日期：2020-07-01 00:00:00

abstract：:β-Caryophyllene (BCP) is a bicyclic sesquiterpene compound that has anti-diabetic activity. However, the effect of BCP on diabetic nephropathy (DN) remains unclear. Here, we aimed to evaluate the potential role of BCP in high glucose (HG)-induced glomerular mesangial cells (MCs). MCs were maintained under HG condition...

journal_title：International immunopharmacology

authors： Li H,Wang D,Chen Y,Yang M

更新日期：2020-07-01 00:00:00

abstract：:Isodeoxyelephantopin (IDET) has been identified as an anti-tumor natural constituent whose anti-tumor activity and mechanism have been widely investigated. Since the occurrence and development of cancer usually accompany with inflammation, and tumor signaling shares many components with inflammation signaling, the age...

journal_title：International immunopharmacology

authors： Han Y,Li X,Zhang X,Gao Y,Qi R,Cai R,Qi Y

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:To illustrate the potential effects and mechanism of extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) on fibrosis in sclerodermatous chronic graft-versus-host-disease (cGVHD) models after allogeneic hematopoietic stem cell transplantation. METHODS:We first observed the therapeutic effects...

journal_title：International immunopharmacology

authors： Guo L,Lai P,Wang Y,Huang T,Chen X,Geng S,Huang X,Luo C,Wu S,Ling W,Huang L,Du X,Weng J

更新日期：2020-07-01 00:00:00

abstract：:The tumor microenvironment is a critical factor that enhances cancer progression, drug resistance, and failure of therapeutic approaches. Several cellular and non-cellular factors are involved in cancer promotion. Among the several cell populations in the tumor microenvironment, macrophages, as one of the most abundan...

journal_title：International immunopharmacology

authors： Yousefzadeh Y,Hallaj S,Baghi Moornani M,Asghary A,Azizi G,Hojjat-Farsangi M,Ghalamfarsa G,Jadidi-Niaragh F

更新日期：2020-07-01 00:00:00

abstract：:The formation of an immunosuppressive microenvironment and up-regulation of PD-L1 protein are the main causes of tumor immune escape. Previous reports suggest that Angiotensin II (Ang II) can modulate the immune status of tumor microenvironment in non-small cell lung cancer (NSCLC), but the underlying mechanism remain...

journal_title：International immunopharmacology

authors： Yang K,Zhou J,Chen Y,Chen Y,Chen L,Zhang P,Ma L,Jiang Z,Bian J,Yin W

更新日期：2020-07-01 00:00:00

abstract：:The Global Program for Elimination Lymphatic Filariasis (GPELF) is in an advanced stage and requires tools for diagnosing infection, assessing transmission and certification. This study was aimed at developing an antibody-based assay using a chiemric antigen containing multi-B-cell epitopes from antigens highly expres...

journal_title：International immunopharmacology

authors： Yasin N,Sugerappa Laxmanappa H,Muddapur UM,Cheruvathur J,Uday Prakash SM,Venkataramaiah Thulasiram H

更新日期：2020-06-01 00:00:00

abstract：:This report sought to establish the mechanistic role of sirtuin-1 (Sirt1), a NAD+-dependent deacetylase in the modulation of primary biliary cholangitis (PBC) pathogenesis. 64 PBC patients (diagnosed based on practice guidelines for American Association for the Study of Liver Diseases) and 60 healthy controls were inc...

journal_title：International immunopharmacology

authors： Li Y,Xi Y,Tao G,Xu G,Yang Z,Fu X,Liang Y,Qian J,Cui Y,Jiang T

更新日期：2020-06-01 00:00:00

abstract：:Lung adenocarcinoma (LUAD) is a frequently diagnosed histologic subtype with increasing morbidity and mortality. RalGDS-Like 4 (RGL4) has not been reported to be associated with cancer risk, prognosis, immunotherapy or any other treatments. We perform a bioinformatics analysis on data downloaded from the Cancer Genome...

journal_title：International immunopharmacology

authors： Sun Y,Zhang Y,Ren S,Li X,Yang P,Zhu J,Lin L,Wang Z,Jia Y

更新日期：2020-06-01 00:00:00

abstract：:Acute lung injury (ALI) is linked with considerable morbidity and mortality. ALI can be caused by various agents, one of them being sepsis. ALI is characterized by injury to vascular endothelium and alveolar epithelium that results in edema, pulmonary immune cells infiltration and hypoxemia. Neutrophils and T cells pa...

journal_title：International immunopharmacology

authors： Nadeem A,Al-Harbi NO,Ahmad SF,Al-Harbi MM,Alhamed AS,Alfardan AS,Assiri MA,Ibrahim KE,Albassam H

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Using a combination of homologous and heterologous (mouse/human) polyclonal anti-idiotypic Igs and immune Igs in BALB/c mice we have previously reported attenuation of allergic type responses following OVA immunization. We have now investigated attenuation of an inflammatory colitis in C57BL/6 mice receiving...

journal_title：International immunopharmacology

authors： Gorczynski RM,Hoffmann G

更新日期：2020-06-01 00:00:00

abstract：:Hereditary Angioedema (HAE) is a rare, autosomal dominant disease caused by mutations in SERPING1 gene leading to dysfunction/deficiency of C1-esterase inhibitor (C1-INH) protein and subsequent dysregulation of the contact system and bradykinin overproduction. As functional C1-INH (fC1-INH) levels are reduced in HAE t...

journal_title：International immunopharmacology

authors： Chockalingam PS,Zhou Z,Garg BK,Boehringer H,Chung R,Fait S

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Epigenetic alternations of microRNAs (miRNAs) can contribute to the pathogenesis and progression of rheumatoid arthritis (RA). This study aimed to measure the expression level of peripheral blood miRNAs, as well as their target mRNAs, in RA patients and healthy controls (HCs), and to evaluate the potential o...

journal_title：International immunopharmacology

authors： Rezaeepoor M,Pourjafar M,Tahamoli-Roudsari A,Basiri Z,Hajilooi M,Solgi G

更新日期：2020-06-01 00:00:00